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afya
Topiramate
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<<forEachTiddler where 'tiddler.tags.contains(context.inTiddler.title)' sortBy tiddler.title ascending write '"*[["+tiddler.title+"]]\n"'>> <<tiddler AutoRefresh with: force>> developed as antiepileptic (alone or adjunctive in generalised tonic-clonic seizures) migraine prophylaxis - BNF - start at 25mg noctefor 1/52 and inc at 25mg steps at weekly intervals - usual dose 50-100mg a day in two divided doses. P450 inducer - so contraception less effective (and teratogenic) - COCP - UKMEC3, Implant - UKMEC2 (Depo and Mirena unaffected) ''Side effects'' weight loss (occurs in >10% people) dizziness paraesthesia lethargy and poor concentration rare but important: acute myopia and secondary angle closure glaucoma less common - insomnia, myalgia and tinnitus
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Migraine