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afya
Thiazolidinediones
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> Agonists of PPAR-gamma receptor so reduce peripheral insulin resistance. Rosiglitazone withdrawn in 2010 - due to cardiovascular side-effects ''PPAR-gamma receptor'' - intracellular nuclear receptor Its natural ligands are free fatty acids and it is thought to control adipocyte differentiation and function. ''Adverse effects'' (WOLFF) weight gain liver impairment: monitor LFTs fluid retention - so contraindicated in heart failure. (risk of fluid retention inc if also on insulin) ? inc risk of fractures ? inc bladder cancer (O) only continue if HbA1C dec by >0.5% over 6/12
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DiabeticMeds