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Agonists of PPAR-gamma receptor so reduce peripheral insulin resistance. 
Rosiglitazone withdrawn in 2010 - due to cardiovascular side-effects

''PPAR-gamma receptor'' - intracellular nuclear receptor 
Its natural ligands are free fatty acids and it is thought to control adipocyte differentiation and function.

''Adverse effects'' (WOLFF)
    weight gain
    liver impairment: monitor LFTs
    fluid retention - so contraindicated in heart failure. (risk of fluid retention inc if also on insulin)
    ? inc risk of fractures
    ? inc bladder cancer (O)

only continue if HbA1C dec by >0.5% over 6/12