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Multiple Myeloma
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clonal proliferation of malignant plasma cells in bone marrow monoclonal protein in blood or urine organ dysfunction complete Ig and fragments usually secreted, but in 25% only fragments - Bence Jones (light) evolves - gammopathy of undetermined clinical significance to smouldering myeloma to symptomatic myeloma presents - anaemia, bone pain / fractures, inc infection, bence-jones proteinuria
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BloodCancer