clonal proliferation of malignant plasma cells in bone marrow
monoclonal protein in blood or urine
organ dysfunction

complete Ig and fragments usually secreted, but in 25% only fragments -
Bence Jones (light)

evolves - gammopathy of undetermined clinical significance to
smouldering myeloma to symptomatic myeloma

presents - anaemia, bone pain / fractures, inc infection, bence-jones
proteinuria