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Loop diuretics
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> Furosemide and Bumetanide Inhibit Na-K-Cl co-transport in ascending limb of loop reducing absorption of NaCl Indications - heart failure (acute (IV) and chronic (oral) resistant HT - esp if renal impairment Adverse effects Hypotension HypoNa HypoK HypoCl alkalosis ototoxicity hypoCa renal impairment (dehydration and direct toxic) HyperGly (less than with thiazides) Gout
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