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Furosemide and Bumetanide
Inhibit Na-K-Cl co-transport in ascending limb of loop reducing absorption of NaCl
Indications - heart failure (acute (IV) and chronic (oral)
resistant HT - esp if renal impairment
 
Adverse effects
Hypotension
HypoNa
HypoK
HypoCl alkalosis
ototoxicity
hypoCa
renal impairment (dehydration and direct toxic)
HyperGly (less than with thiazides)
Gout