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afya
Dabigatran
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<<forEachTiddler where 'tiddler.tags.contains(context.inTiddler.title)' sortBy tiddler.title ascending write '"*[["+tiddler.title+"]]\n"'>> <<tiddler AutoRefresh with: force>> oral anticoagulant - direct thrombin inhibitor. developed as an alternative to warfarin - not require regular monitoring. prophylaxis of venous thromboembolism following hip or knee replacement surgery. prevention of stroke in non-valvular AF with one of ... previous stroke, transient ischaemic attack or systemic embolism left ventricular ejection fraction below 40% symptomatic heart failure of New York Heart Association (NYHA) class 2 or above age 75 years or older age 65 years or older with one of the following: diabetes mellitus, coronary artery disease or hypertension ''Adverse effects'' haemorrhage reduce in CKD (avoid if creatinine clearance is < 30 ml/min) Note ... RE-ALIGN study - higher bleeding and thrombotic events with recent mechanical heart valve replacement - dabigatran cf warfarin (so use warfarin) ie CI in pts with mechanical heart valves
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Thrombophylaxis