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afya Dabigatran

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20160425222426 Ben  
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oral anticoagulant - direct thrombin inhibitor. 
developed as an alternative to warfarin - not require regular monitoring.

prophylaxis of venous thromboembolism following hip or knee replacement surgery. 

prevention of stroke in non-valvular AF with one of ...
previous stroke, transient ischaemic attack or systemic embolism
left ventricular ejection fraction below 40%
symptomatic heart failure of New York Heart Association (NYHA) class 2 or above
age 75 years or older
age 65 years or older with one of the following: diabetes mellitus, coronary artery disease or hypertension

''Adverse effects''
haemorrhage 
reduce in CKD (avoid if creatinine clearance is < 30 ml/min)

Note ...
RE-ALIGN study - higher bleeding and thrombotic events with recent mechanical heart valve replacement  - dabigatran cf warfarin (so use warfarin)
ie CI in pts with mechanical heart valves