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Cytotoxics
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<<forEachTiddler where 'tiddler.tags.contains(context.inTiddler.title)' sortBy tiddler.title ascending write '"*[["+tiddler.title+"]]\n"'>> <<tiddler AutoRefresh with: force>> |Cytotoxic|Mechanism of action|Adverse effects| ''Alkylating agent'' |Cyclophosphamide|Alkylating agent - causes cross-linking in DNA|Haemorrhagic cystitis, myelosuppression, transitional cell carcinoma| ''Cytotoxic antibiotics'' |Bleomycin|Degrades preformed DNA|Lung fibrosis| |Doxorubicin|Stabilizes DNA-topoisomerase II complex inhibits DNA & RNA synthesis|Cardiomyopathy| ''Antimetabolites'' |Methotrexate|Inhibits dihydrofolate reductase and thymidylate synthesis|Myelosuppression, mucositis, liver fibrosis, lung fibrosis| |Fluorouracil (5-FU)|Pyrimidine analogue inducing cell cycle arrest and apoptosis by blocking thymidylate synthase (works during S phase)|Myelosuppression, mucositis, dermatitis| |6-mercaptopurine|Purine analogue that is activated by HGPRTase, decreasing purine synthesis|Myelosuppression| |Cytarabine|Pyrimidine antagonist. Interferes with DNA synthesis specifically at the S-phase of the cell cycle and inhibits DNA polymerase|Myelosuppression, ataxia| ''Acts on microtubules'' |Vincristine|Inhibits formation of microtubules|Peripheral neuropathy (reversible) , paralytic ileus,| |Vinblastine||myelosuppression| |Docetaxel|Prevents microtubule depolymerisation & disassembly, decreasing free tubulin|Neutropaenia| ''Other cytotoxic drugs'' |Cisplatin|Causes cross-linking in DNA|Ototoxicity, peripheral neuropathy, hypomagnesaemia| |Hydroxyurea (hydroxycarbamide)|Inhibits ribonucleotide reductase, decreasing DNA synthesis|Myelosuppression|
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Cancer, Drugs