<<forEachTiddler  where 'tiddler.tags.contains(context.inTiddler.title)'
sortBy 
        tiddler.title
    ascending 
write '"*[["+tiddler.title+"]]\n"'>>
<<tiddler AutoRefresh with: force>>

|Cytotoxic|Mechanism of action|Adverse effects|

''Alkylating agent''
|Cyclophosphamide|Alkylating agent - causes cross-linking in DNA|Haemorrhagic cystitis, myelosuppression, transitional cell carcinoma|

''Cytotoxic antibiotics''
|Bleomycin|Degrades preformed DNA|Lung fibrosis|
|Doxorubicin|Stabilizes DNA-topoisomerase II complex inhibits DNA & RNA synthesis|Cardiomyopathy|

''Antimetabolites''
|Methotrexate|Inhibits dihydrofolate reductase and thymidylate synthesis|Myelosuppression, mucositis, liver fibrosis, lung fibrosis|
|Fluorouracil (5-FU)|Pyrimidine analogue inducing cell cycle arrest and apoptosis by blocking thymidylate synthase (works during S phase)|Myelosuppression, mucositis, dermatitis|
|6-mercaptopurine|Purine analogue that is activated by HGPRTase, decreasing purine synthesis|Myelosuppression|
|Cytarabine|Pyrimidine antagonist. Interferes with DNA synthesis specifically at the S-phase of the cell cycle and inhibits DNA polymerase|Myelosuppression, ataxia|

''Acts on microtubules''
|Vincristine|Inhibits formation of microtubules|Peripheral neuropathy (reversible) , paralytic ileus,|
|Vinblastine||myelosuppression|
|Docetaxel|Prevents microtubule depolymerisation & disassembly, decreasing free tubulin|Neutropaenia|

''Other cytotoxic drugs''
|Cisplatin|Causes cross-linking in DNA|Ototoxicity, peripheral neuropathy, hypomagnesaemia|
|Hydroxyurea (hydroxycarbamide)|Inhibits ribonucleotide reductase, decreasing DNA synthesis|Myelosuppression|