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Bisphosphonates
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<<forEachTiddler where 'tiddler.tags.contains(context.inTiddler.title)' sortBy tiddler.title ascending write '"*[["+tiddler.title+"]]\n"'>> <<tiddler AutoRefresh with: force>> analogues of pyrophosphate - decreases demineralisation in bone inhibit osteoclasts by reducing recruitment and promoting apoptosis ''Clinical uses'' prevention and treatment of osteoporosis hypercalcaemia Paget's disease pain from bone metatases ''Adverse effects'' oesophageal reactions: oesophagitis, oesophageal ulcers (especially alendronate) osteonecrosis of the jaw increased risk of atypical stress fractures of the proximal femoral shaft in patients taking alendronate ''BNF counselling'' - 'Tablets should be swallowed whole with plenty of water while sitting or standing; to be given on an empty stomach at least 30 minutes before breakfast (or another oral medication); patient should stand or sit upright for at least 30 minutes after taking tablet'
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