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analogues of pyrophosphate - decreases demineralisation in bone
inhibit osteoclasts by reducing recruitment and promoting apoptosis

''Clinical uses''
    prevention and treatment of osteoporosis
    hypercalcaemia
    Paget's disease
    pain from bone metatases

''Adverse effects''
    oesophageal reactions: oesophagitis, oesophageal ulcers (especially alendronate)
    osteonecrosis of the jaw
    increased risk of atypical stress fractures of the proximal femoral shaft in patients taking alendronate

''BNF counselling'' - 'Tablets should be swallowed whole with plenty of water while sitting or standing; to be given on an empty stomach at least 30 minutes before breakfast (or another oral medication); patient should stand or sit upright for at least 30 minutes after taking tablet'