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Alzheimers
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<<forEachTiddler where 'tiddler.tags.contains(context.inTiddler.title)' sortBy tiddler.title ascending write '"*[["+tiddler.title+"]]\n"'>> <<tiddler AutoRefresh with: force>> progressive degenerative disease of brain accounts for majority of dementia in UK ''Genetics'' most cases are sporadic 5% inherited as autosomal dominant trait - / related to mutations in amyloid precursor protein (chromosome 21), presenilin 1 (chromosome 14) and presenilin 2 (chromosome 1) apoprotein E allele E4 - encodes a cholesterol transport protein ''Pathological changes'' macroscopic = widespread cerebral atrophy, particularly involving the cortex and hippocampus microscopic = intraneuronal neurofibrillary tangles, neuronal plaques, deficiency of neurons biochemical = deposition of type A-Beta-amyloid protein in cortex, deficit of Ach from damage to an ascending forebrain projection ''Neurofibrillary tangles'' paired helical filaments are partly made from a protein called tau in AD tau proteins are excessively phosphorylated ''Management'' NICE - acetylcholinesterase inhibitors (donepezil, galantamine and rivastigmine) for mild to moderate Alzheimer's disease memantine (a NMDA receptor antagonist) is reserved for patients with moderate - severe Alzheimer's
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Dementia