This google groups thread has some information on installation TiddlyWeb on Fedora. Also pasted here are the highlights:

• Install packages: {{{ sudo yum install -y python-virtualenv }}}
• Install TiddlyWeb: {{{ virtualenv python-tweb . python-tweb/bin/activate sudo pip install -U tiddlywebwiki }}}
• Setup TiddlyWeb: {{{ twinstance tweb cd tweb

I already have a service on 8080

twanager server 127.0.0.1 8888 & }}} Import Existing Content: {{{ twanager twimport common file:///path/to/previous/tiddlywiki.html }}} Visit The Stuff: {{{ http://127.0.0.1:8888/recipes/default/tiddlers.wiki }}}