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Nephroblastoma
one of common childhood malignancy
usually <5 (average 3yr)

features
abdo mass
flank pain
painless haematuria
anorexia fever
95% unilat
20% mets (usually lung) on presentation

associations
Beckwith-Wiederman
WAGR syndrome - aniridia, GU malformation, mental retardation
hemihypertrophy
1/3 have mutation in WT1 gene on chromosome 11

Mx
Nephrectomy
Chemo
Radio if advanced
good prognosis - 80% cure