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afya Type2NICE2009Mx

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20160425222512 Ben  
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''Diet''
high fibre, low glycaemic index CHO
low-fat dairy, oily fish - good
limit saturated fats and trans fatty acids
limit sucrose substitute (avoid xs energy intake) 
discourage specific diabetic foods
weight loss - initial target  if  overweight 5-10%

''HbA1c''
overall  target  48 (6.5%) (not less) but needs to be individualised
check 2-6/12ly till stable, then 6/12thly

''BP''
target < 140/80 (or < 130/80 if end-organ damage present)
ACE inhibitors first-line

treatment algorithm - complex ...
lifestyle first
1st line -  metformin (?start on diagnosis)
then sulfonylurea if  HbA1c still  > 48 
avoid sulphonylurea and consider other if .... 
worries over hypo risk - DPP-4 inhibitor or thiazolidinedione
erratic lifestyle - meglitinides (insulin secretagogues) 

if ''HbA1c > 58'' (7.5%) consider insulin
continue metformin with  insulin
use exenatide if needs insulin but obesity (BMI >35) so high dose insulin will be needed
Continue only if beneficial response occurs and is maintained (> 1.0% HbA1c loss and >3% wt loss at 6/12)

''Starting insulin''
if HbA1c >58 
start with NPH (isophane, intermediate acting) at bed-time or bd

''Other''
aspirin to all > 50y and to younger if other risk factors (still in NICE, no longer in SIGN - latest evidence not support aspirin in primary prevent)
lipids - >40y without risk factors (smoking, obese, HT) and CVS 10yr risk <20% - don't need ...
use Simva 40 - if target not reached inc to Simva 80 then atorva, then ezetimibe
target total cholesterol < 4.0
fenofibrate if TG >4.5