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20160425222549 Ben  
<<forEachTiddler  where 'tiddler.tags.contains(context.inTiddler.title)'
sortBy 
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write '"*[["+tiddler.title+"]]\n"'>>
<<tiddler AutoRefresh with: force>>

''Overview''
    shown to be as effective as tricyclic antidepressants in the treatment of mild-moderate depression
    mechanism: thought to be similar to SSRIs (although noradrenaline uptake inhibition has also been demonstrated)
    NICE advise 'may be of benefit in mild or moderate depression, but its use should not be prescribed or advised because of uncertainty about appropriate doses, variation in the nature of preparations, and potential serious interactions with other drugs'

''Adverse effects''
    profile in trials similar to placebo
    can cause serotonin syndrome
    inducer of P450 system, therefore decreased levels of drugs such as warfarin, ciclosporin. The effectiveness of the combined oral contraceptive pill may also be reduced