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''Isotretinoin, Acitretin''

oral retinoid used in treatment of severe acne. 
2/3 patients have a long term remission or cure following a course of oral isotretinoin

''Adverse effects'' (ISOTTT)
    I - benign intracranial hypertension - so don't  combine with tetracyclines 
S - skin - dry (most common SE) skin eyes lips, nasal mucosa (causes nose bleeds) AND photosensitivity
O-lOw mOOd
T - teratogenicity: females use two forms of contraception (e.g. Combined oral contraceptive pill and condoms)
T - raised triglycerides
T - hair thinning