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many antibiotics lower seizure threshold - esp quinolones - so use with caution in epilepsy or conditions that predispose to seizures

group of antibiotics which work by inhibiting DNA synthesis and are bactericidal in nature (inhibit topoisomeras II (DNA gyrase) and IV)
eg ciprofloxacin, levofloxacin

''Adverse effects''
lower seizure threshold in patients with epilepsy
tendon damage (including rupture) - esp with steroids
? cartilage damage - avoid in kids