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1 in 7 adults in UK
Many will progress to T2DM so inc risk both micro and macro vascular
Term pre-diabetes is best understood by public
assess risk in all over 40, over 20 if chinese, south-asian or any condition inc risk and do blood test
''Fasting glc 5.5-6.9, HbA1C 43-47 (6-6.4%)'' suggests high risk
''Mx''
lifestyle modification - wt loss, exercize, diet change
yearly repeat bloods
consider metformin (start if lifestyle change occurs but still worsening of HbA1C)
''2 types''
''Impaired Fasting Glucose''
due to hepatic insulin resistance (less serious)
fasting glucose 6.1-7.0
needs OGTT
''Impaired Glucose Tolerance''
due to to muscle insulin resistance
more likely to progress and develop CVS disease
fasting glc <7 with 2hr post load 7.8-11.1