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afya Huntingdon's

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20160425222541 Ben  
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<<tiddler AutoRefresh with: force>>

inherited neurodegenerative condition. 
progressive and incurable condition that typically results in death 20 years after the initial symptoms develop.

''Genetics''
    autosomal dominant
    trinucleotide repeat disorder: repeat expansion of CAG
    results in degeneration of cholinergic and GABAergic neurons in the striatum of the basal ganglia
    due to defect in huntingtin gene on chromosome 4

''Features typical develop after 35 years of age''
    chorea
    personality changes (e.g. irritability, apathy, depression) and intellectual impairment
    dystonia
    saccadic eye movements