Female androgenetic alopecia from top of scalp - usually just general loss / widened parting - no broken hairs, Normal scalp, usually hairs miniaturise to thinner finer and so to vellus hairs (non-pigmented thin fine short hairs) never on occiput, seldom from sides - think hypothyroid or Iron deficiency (diffuse) different patturn to males - although Male patturn may occur in females - check androgens but usually normal generally slow progressive - rarely start in adolescence complex inheritance may relate to depression Mx Finasteride (5a red inhibit - stops Testos to dihydroT) - works for men, pre-men women - avoid as teratogenic, post-men - not effective Steroids / Ketoconazole - doesn't work Laser - little evidense 2% Minoxidil - some evidense (60% effective), not on NHS, use for 4-6 /12 if effective will need to continue to maintain, if not effective by 6/12 abandon or may respond to Anti-androgens .... (dec miniaturisation) Cyproterone acetate - need contraception Spironolactone SE cyproterone irregular menses, loss libido, fatigue, wt change, breast tender, hepatotoxic, depression SE Spironolactone Hyperkalaemia (avoid in renal failure) feminisation of male fetus