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acute, self-limiting, recurrent
hypersensitivity reaction to infection and medication
target lesions ? blister at centre, symmetrical peripheral (usually limbs)
20-40yr, F esp with HIV

drugs - barbiturates, sulphonamides, aspirin
infection - ''HSV'', typhoid, mycoplasma, TB, orf
inflammation - inflammatory bowel, collagen vascular disease, allergy
other - vitamin A,B6,C deficiency, pregnancy, post-radiation, 

Mx
treat underlying condition - if recurrent may need propyhlactic acyclovir for HSV
antihistamine if itch
topical steroid ??oral steroid
avoid 2ndary infection and dehydration
may take 3/52 to resolve

? separate entity but similar
Steven Johnson Syndrome and Toxic Epidermal Necrolysis