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used in the management of cardiovascular disease. 
Voltage-gated calcium channels - myocardial cells, cells of the conduction system, vascular smooth muscle. 
various types of CCB have varying effects on these three areas

|Examples|Indications|Inotropic - Heart Failure|Side-effects|
|Verapamil|Angina, hypertension, arrhythmias|Highly negatively inotropic - don't  give with beta-blockers - heart block|Heart failure, constipation, hypotension, bradycardia, flushing|
|Diltiazem|Angina, hypertension|Less negatively inotropic than verapamil - caution in heart failure or beta-blockers|Hypotension, bradycardia, heart failure, ankle swelling|
|Nifedipine, amlodipine, felodipine (dihydropyridines)|Hypertension, angina, Raynaud's|peripheral vascular smooth muscle > myocardium - don't worsen heart failure|Flushing, headache, ankle swelling|