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caused by a monoclonal proliferation of well-differentiated lymphocytes which are almost always B-cells (99%)

''Features''
often none
constitutional: anorexia, weight loss
bleeding, infections
lymphadenopathy more marked than CML

''Complications''
hypogammaglobulinaemia leading to recurrent infections
warm autoimmune haemolytic anaemia in 10-15% of patients
transformation to high-grade lymphoma (Richter's transformation)

''Investigations''
blood film: smudge cells
immunophenotyping