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Note gynaecomastia - Spironolactone, Digoxin, Cimetidine
Amiodarone adverse effects.
thyroid dysfunction: both hypothyroidism and hyperthyroidism
corneal deposits: present in most patients, rarely interfere with vision, usually reversible on withdrawal of drug
pulmonary fibrosis/pneumonitis
liver cirrhosis/hepatitis
peripheral neuropathy, myopathy
photosensitivity
'slate-grey' appearance
prolonged QT interval
thrombophlebitis and injection site reactions
bradycardia
Important drug interactions of amiodarone include:
decreased metabolism of warfarin, therefore increased INR
increased digoxin levels