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afya AcneVulgarisMx

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20160425222552 Ben  
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''simple step-up scheme'' 6/52 at each level, alt days to start with
//Mild// 
single topical therapy (retinoids (comedones) or benzyl peroxide (pustules))
then topical combination therapy (2 of - antibiotic, benzoyl peroxide, retinoid)
//Moderate//
Consider COCP, then add in oral antibiotics with BP or topical reinoids
try two different oral abs for 8/52 each before referral
//Severe//
oral isotretinoin: only under specialist supervision

therapy – 3-6/52 to help, 3-6/12 for max effect
lifestyle – diet no difference, smoking inc, skin cleansers help with mild
topical antibiotics – erythro, clinda (as good as oral), 
Oral antibiotics - oxytet (od most cost effective), doxy, erythro, for larger area – 12/52 at most and use with retinoid or BP to dec resistance, 
Beware – tetracyclines for children, young women – need contraceptive
Azelaic acid – limited benefit
COCP (Dianette not shown to be better than any other but POP may make skin worse)
Retinoids – teratogenic, specialist prescribe oral, 16-24/52 course, beware suicide

Minocycline - possible irreversible pigmentation - AVOID
Gram negative folliculitis may occur with long-term antibiotic use - high-dose oral trimethoprim is effective if this occurs but may depress haematopoiesis - specialist to start
Erythromycin - inhibits P450 so affects hepatic metabolism of other drugs