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afya AbnormalLFT

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20160425222536 Ben  
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see patient .co.uk


''bilirubin''
breakdown of haem, binds to albumin, conjugated by liver, lost in urine

''albumin''
chronic marker

''total protein''
albumin + globulin (as one rises, other falls)
high in chronic active or alcoholic hepatitis

''ALT/AST''
show hepatocellular damage esp ALT
AST also in skeletal muscle (Creatinine Kinase) or Heart (troponin)
high ALT (>1000) - PCM, acute hep A/B, ischaemia, autoimmune
ratio can be useful

''GGT''
helps show specific to liver damage but raised in many liver diseases

''Alk Phos''
from bile duct and bone
so if GGT also high - then cholestasis, if normal then bone

Check ... travel, transfusion, alcohol
Exam - liver stigma, hepatosplenomegaly, ascites, obesity