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afya
SIADH
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> HypoNa secondary to dilutional effect of xs water retention ''Causes'' ''Malignancy'' - //small cell lung cancer//, pancreas prostate ''Neurological'' - stroke, SAH, subdural heamorrhage, meningitis/encephalitis/abscess ''Infections'' - TB, Pneumonia ''Drugs'' - Sulphonylureas (//Gliclazide//), SSRI/Tricyclic, Carbamazepine, Vincristine, Cyclophosphamide ''Other'' - PEEP, Porhpyrias ''Mx'' Correct slowly to avoid precipitating central pontine myelinolysis Fluid restrict demeclocycline - reduces tubule responsiveness to ADH ADH receptor antagonists are being developed
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