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Prolonged QT interval
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<<forEachTiddler where 'tiddler.tags.contains(context.inTiddler.title)' sortBy tiddler.title ascending write '"*[["+tiddler.title+"]]\n"'>> <<tiddler AutoRefresh with: force>> start QRS to end T (duration of activation and recovery of ventricular myometrium) so if prolonged next depolarisation may be incomplete and contraction ineffective If >0.44 secs associated with ventricular arrythmyias, syncope and sudden death If >500 or torsade de point - refer ''causes'' drugs hypo - K,Mg,Ca,thermia congenital - AD and AR, FH sudden death (cardiac <40yrs) Avoid drug if possible if underlying cardiac disease Avoid drug if possible if on other drugs that prolong QT If inc risk of arrhythmias monitor Ca, K, Mg ''Drugs'' Tricyclic - Amitryp Anti-arrhythmic - amiod, sotalol anti-histamine - terfenadine, astemizole anti-malarial - halofantrine anti-psychotics - droperidol, thioridazine cisapride methodone, cocaine citalopram and escitalopram
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