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MotorNeuroneDisease
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<<forEachTiddler where 'tiddler.tags.contains(context.inTiddler.title)' sortBy tiddler.title ascending write '"*[["+tiddler.title+"]]\n"'>> <<tiddler AutoRefresh with: force>> ''features'' unknown cause presents with upper and lower motor neuron signs rare before 40yr various patterns - amyotrophic lateral sclerosis, progressive muscular atrophy and bulbar palsy ''clues'' fasciculation (always think MND) absence of sensory signs/symptoms (may have vague symptoms early on but no signs) LMN arms, UMN legs wasting of the small hand muscles/tibialis anterior is common Note no ocular muscle signs no cerebellar signs abdominal reflexes usually preserved and sphincter dysfunction if present is a late feature Diagnosis is clinical nerve conduction studies help exclude neuropathy Electromyography - reduced number action potentials with inc amplitude MRI done to exclude cervical cord compression and myelopathy
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Neurology