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Lipid Trials
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<<forEachTiddler where 'tiddler.tags.contains(context.inTiddler.title)' sortBy tiddler.title ascending write '"*[["+tiddler.title+"]]\n"'>> <<tiddler AutoRefresh with: force>> ''4S trial'' 1994 Scandinavian Simvastatin Survival Study double-blind RCT secondary prevention CVD Pts with IHD and chol 5.5-8.0 - given simvastatin or placebo Result - Total mortality dec by 30%, IHD mortality dec by 42%, no inc in non-CVD death ''WOSCOPS'' 1995 West of Scotland Coronary Prevention Study RCT men 45-64 no Hx IHD with raised chole (>6.5) given pravastatin or placebo Result - total mortality dec by 22%, IHD mortality dec by 31% ''Heart Protection Study'' 2002 MRC RCT (20,000pts) 40 - 80 yrs with 'substantial' 5yr IHD mortality risk (Hx vascular disease, HT or diabetes) Simvastatin 40, antioxidants (600 mg vit E, 250 mg vit C, 20 mg beta-carotene daily), placebo or combination Results - NNT to prevent all cause death = 57, IHD death = 85, vascular event = 19, major coronary event = 33, stroke = 73 vascular events reduced by 25% antioxidants did not affect clinical outcome
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